Los Alamos is about 100 driving miles from Albuquerque, Driving time is approximately 1 hour and 45 minutes. Albuquerque Sunport is an international airport served by multiple national air carriers.

Los Alamos is 35 miles and about a forty minute drive from Santa Fe, a city with an international reputation for Southwest culture, arts, and cuisine. There is scheduled air service from Santa Fe Regional Airport to Dallas (DFW) and Los Angeles (LAX).

Los Alamos has an active general aviation airport.